When you are planning your preclinical development setup it is important to know that the model system you are applying translates well into human use. This may be challenging to predict, even if you have previous data from similar, but not identical setups.
However, if your preclinical model system does not translate well into human use, you may make conclusions that are based on an uncertain biological translational foundation and thus jeopardize significant investments in time and money during your preclinical work.
Intomics track record
We have helped pharmaceutical companies with translations from animal models to humans for a range of disease areas. In some projects we identified areas where translation from animal model to human were well preserved, but in others we demonstrated that only parts of the implicated phenotypical traits from humans were present in the same regulatory structure in the chosen animal model system. In the latter situation, the model system may not sufficiently mimic the human application.
The value to our customers
Performing this translational investigation ensures that you have the highest probability of success in the transition from the preclinical to clinical phase.
What we do
For our preclinical model Translation Service, we perform an in-depth search of the reaction or pathway that your drug is aimed at, and elucidate how this is structured and regulated both in the model systems of interest and in humans. The search is performed by applying our highly optimized InBioTM Data Integration software to searches in our own proprietary InBioTM databases as well as client and publicly available databases.
The duration of a Preclinical model Translation project typically ranges from 4-6 months for a pilot project up to a number of years for long-term projects. The projects are planned as a custom tailored project with close interaction between our clients and Intomics. We typically have bi-weekly Webex update/planning meetings with the client and have face-to-face meetings every 2-3 months during the project.
At the end of the project, we present the process, key findings, conclusions and potential next steps at a face-to-face meeting.
All face-to-face meetings take place at our clients’ facility, unless another location is desired.
What we deliver
The deliverable is an overview of the reaction or pathway of interest, showing all relevant reactions and pathway structures in humans as well as the animal systems of interest.
Additionally, the comprehensive report also details key project findings as well as important process steps and materials. We will also present potential next steps in the project, if relevant.
For more information, please contact us.