Biomarker Discovery Services

Background
A biomarker is a measurable indicator of the severity or presence of a specific disease state.

It indicates a change in expression or state of a biomolecule that correlates with the risk or progression of a disease, or with the susceptibility of the disease to a given treatment.

Biomarkers are applied in a number of ways, including measuring the progress of disease, evaluating the most effective therapeutic regimes for a particular disease, and establishing long-term susceptibility to a disease or its recurrence.

In molecular terms, biomarkers are the subset of markers that might be discovered using genomics, proteomics or similar investigations. Biomarkers help in many areas, including early diagnosis, disease prevention, drug target identification and drug response.

 

Intomics track record
Intomics has been involved in several biomarker discovery projects where expression data, genomics information, protein networks, and literature mining were combined to identify novel biomarkers – often with a validation accuracy exceeding 90 %.

 

The value to our customers
Identifying the right biomarker(s) for a disease or disease state is an important step in making the process of drug discovery more efficient and cost-effective. As examples, optimized biomarkers can enable better patient stratification for clinical trials and better targeting of drugs (e.g. in companion diagnostics). Both of these will significantly improve the probability of meeting the significance requirements for drug approval.

 

What we do
Based on a thorough discussion and description of our clients’ needs we perform in-depth data mining by applying our proprietary InBioTM data mining platform to a combination of our own proprietary value-added InBioTM databases as well as client and publicly available databases.

 

Our process
The duration of a Biomarker Identification project typically ranges from 4-6 months for a pilot project up to a number of years for long-term projects. The projects are planned as a custom tailored project with close interaction between our clients and Intomics. We typically have bi-weekly Webex update/planning meetings with the client and have face-to-face meetings every 2-3 months during the project.

At the end of the project, we present the process, key findings, conclusions and potential next steps at a face-to-face meeting.

All face-to-face meetings take place at our clients’ facility, unless another location is desired.

 

What we deliver
In our comprehensive project report, we deliver a prioritized list of potential biomarkers, with strong documentation to motivate each biomarker.

Additionally, the report also details key project findings as well as important process steps and materials. We will also present potential next steps in the project, if relevant.

For more information, please contact us

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